Since its introduction in 2010, the majority of the company’s current models, including the W205 and W222, have been equipped with the 3.5-liter Mercedes M276 V6 engine. Two atmospheric and turbocharged versions of this power unit are available.

M112 E24, M112 E26, M112 E28, M112 E32, M112 E37, M272 E25, M272 E30, M272 E35, M276 DE30, and M276 DE35 are all members of the V6-family.
Specifications
| Production years | since 2010 |
| Displacement, cc | 3498 |
| Fuel system | direct injection CGI |
| Power output, hp | 252 (M 276 DES 35 red.) 306 (M 276 DES 35) 333 (M 276 DES 35 LA) |
| Torque output, Nm | 340 (M 276 DES 35 red.) 370 (M 276 DES 35) 480 (M 276 DES 35 LA) |
| Cylinder block | aluminum V6 |
| Block head | aluminum 24v |
| Cylinder bore, mm | 92.9 |
| Piston stroke, mm | 86 |
| Compression ratio | 12.0 (M 276 DES 35 red.) 12.2 (M 276 DES 35) 10.7 (M 276 DES 35 LA) |
| Features | no |
| Hydraulic lifters | yes |
| Timing drive | chain |
| Phase regulator | yes |
| Turbocharging | no (M 276 DES 35 red.) no (M 276 DES 35) yes (M 276 DES 35 LA) |
| Recommended engine oil | 5W-30 |
| Engine oil capacity, liter | 8.0 |
| Fuel type | petrol |
| Euro standards | EURO 5/6 |
| Fuel consumption, L/100 km (for Mercedes E300 2015) — city — highway — combined |
9.5 5.6 7.0 |
| Engine lifespan, km | ~300 000 |
| Weight, kg | 172 |
Disadvantages of the M276 DE35 engine
The timing chain tensioners are the part of this power unit that causes the most trouble.
You will need to replace the timing kit with phase regulators if you fail to notice their failure.
These engines also frequently have displaced impulse disks on their camshafts.
Fuel quality has an impact on direct injection injectors.
There have been a few reports of catalyst crumb-related scuffing on specialized forums.
