In 2007, the 5.0-liter Toyota 2UR-GSE engine was released for use in sports Lexus vehicles. This motor is intriguing because it has unique Yamaha cylinder heads, titanium valves, and a combined fuel injection system that combines distributed MPI and direct D4-S.

The engines in the UR family are 1URFE, 1URFSE, 2URGSE, 2URFSE, and 3URFE.
The engine was mounted on:
- Lexus GS-F L10 since 2015;
- Lexus IS-F XE20 in 2007 – 2014;
- Lexus LC 500 URZ100 since 2016;
- Lexus RC-F XC10 since 2014.
Specifications
| Production years | since 2007 |
| Displacement, cc | 4969 |
| Fuel system | combined injection |
| Power output, hp | 416 – 477 |
| Torque output, Nm | 503 – 540 |
| Cylinder block | aluminum V8 |
| Block head | aluminum 32v |
| Cylinder bore, mm | 94 |
| Piston stroke, mm | 89.5 |
| Compression ratio | 11.8 – 12.3 |
| Features | ACIS and ETCS-i |
| Hydraulic lifters | yes |
| Timing drive | chain |
| Phase regulator | Dual VVT-i |
| Turbocharging | no |
| Recommended engine oil | 5W-30 |
| Engine oil capacity, liter | 8.6 |
| Fuel type | petrol |
| Euro standards | EURO 5 |
| Fuel consumption, L/100 km (for Lexus RC-F 2016) — city — highway — combined |
16.1 7.8 10.8 |
| Engine lifespan, km | ~300 000 |
| Weight, kg | 224 |
Disadvantages of the 2UR-GSE engine
Owners have complained about the unit’s moderate oil consumption of up to 0.5 liters per 1000 kilometers; some have already had to decarbonize because of stuck rings; there have been instances of the hydraulic chain tensioner and pump breaking down at low mileage; overall, the unit’s reliability is very good.
