The OM346 is a 10.8-liter direct-injection engine with six cylinders. Like all OM 300 series engines, the cylinders are arranged in an in-line configuration.

Mercedes-Benz buses and medium and heavy trucks were the primary application areas. The newly created OM 400 series motors started to replace the engines around 1970, but production didn’t end until 1978.
Specifications
| Engine’s type | diesel |
| Also called | OM 346 h |
| Production years | 01.1964 |
| Power output, kW (hp) | 132 (180), 149 (202) (154 with switchable fan) at 2200 rpm |
| Displacement, cc | 10809 |
| Number of cylinders | 6 |
| Valves | 12 |
| Compression ratio (compression) | 17.5:1 |
| Cylinder bore, mm | 128 |
| Piston stroke, mm | 140 |
| Crankshaft bearings | 7 |
| Configuration | inline |
| Fuel type | diesel |
| Fuel system | direct injection |
| Turbine | intake |
| Cylinder head | OHV |
| Timing mechanism | spur gear |
| Timing | rocker arm |
| Cooling | water |
Modifications
OM 346.910: 6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 155 kW (210 horsepower), two valves per cylinder. published between 1964 and 1978. For Mercedes-Benz models 19–1920, 26–2620, 16–1620, and 22–2220.
OM 346.911—6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 155 kW (210 horsepower), two valves per cylinder. published between 1964 and 1978. for models of Mercedes Benz O317.
OM 346.912—6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 155 kW (210 horsepower), two valves per cylinder. produced between 1.1964 and 9.1967. Regarding Mercedes-Benz models 19t-1920, 16t-1620, 16t-1623, 22t-2220, 20t-2020, and 20t-2023.
OM 346.913: 6-cylinder, 10809 cc, 140 stroke, 128 bore, 155 kW (210 horsepower), two valves per cylinder. published between 1964 and 1978. For Mercedes-Benz 19t-1920, 26t-2620, 24t-2420, 16t-1620, and 22t-2220.
OM 346.914—6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 136 kW (185 horsepower), two valves per cylinder. published between 1964 and 1978. For Mercedes-Benz models 19t-1918, 16t-1618, and 14t-1418.
OM 346.915: 6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 136 kW (185 horsepower), two valves per cylinder. produced between 1.1964 and 12.1969. For Mercedes-Benz models 14t–1418.
OM 346.916: 6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 136 kW (185 horsepower), two valves per cylinder. produced between 1.1966 and 12.1973. For Mercedes-Benz models 15t–1518.
OM 346.917: 6-cylinder, 10809 cc, 140 stroke, 128 bore, 155 kW (210 horsepower), two valves per cylinder. produced between 1.1966 and 12.1973. For Mercedes-Benz models 19t-1920 and 19t-1923.
OM 346.918: 6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 136 kW (185 horsepower), two valves per cylinder. published between 1964 and 1978. Regarding Mercedes-Benz O 317, (O317).
OM 346.919 is a Mercedes Benz Industrial engine with six cylinders, 10809 cc, two valves per cylinder, 140 strokes, and a bore of 128.
OM 346.940 is a Mercedes Benz Industrial engine with six cylinders, 10809 cc, two valves per cylinder, 140 strokes, and a bore of 128.
OM 346.941: 6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 155 kW (210 horsepower), two valves per cylinder. produced between 1.1964 and 12.1969. For Mercedes-Benz models 3T-326 and 3T-334.
OM 346.942: 6-cylinder, 10809 cc, 140 stroke, 128 bore, 155 kW (210 horsepower), two valves per cylinder. produced between 1.1964 and 12.1969. For Mercedes-Benz models 3T-326, 3T-333, and 3T-334.
OM 346.943: 6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 136 kW (185 horsepower), two valves per cylinder. produced between 1.1964 and 12.1969. Regarding Mercedes-Benz models 3t-329, 3t-331, and 3t-332.
OM 346.944: 6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 136 kW (185 horsepower), two valves per cylinder. produced between 1.1964 and 12.1969. Regarding Mercedes-Benz models 3t-329, 3t-331, and 3t-332.
OM 346.945: 6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 136 kW (185 horsepower), two valves per cylinder. produced between 1.1964 and 12.1969. Regarding Mercedes-Benz models 3t-329, 3t-331, and 3t-332.
OM 346.946: 6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 136 kW (185 horsepower), two valves per cylinder. produced between 1.1964 and 12.1969. For Mercedes-Benz models 14t–1418.
OM 346.947: Mercedes-Benz Industrial engine, 6-cylinder, 10809 cc, 140 stroke, 128 bore, 2 valves per cylinder.
OM 346.951 is a Mercedes-Benz industrial engine with six cylinders, 10809 cc, two valves per cylinder, 140 strokes, and a bore of 128.
OM 346.952: 6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 141 kW (192 horsepower), two valves per cylinder. produced between 1.1964 and 12.1969. For Mercedes-Benz models 16t–1619.
OM 346.953: 6-cylinder, 10809 cc displacement, 140 stroke, 128 bore, 136 kW (185 horsepower), two valves per cylinder. produced between 1.1964 and 12.1969. For Mercedes-Benz models 14t–1418.
